Table 3.

Baseline Risk Factors For CVD Subgroup, 1 to 5 Years After Cancer Diagnosis Among Thyroid Cancer Survivors (N = 3822)

Variable	CVD Subgroup
	Hypertension (n = 1075)	Heart Disease (n = 968)	Cerebrovascular Disease (n = 125)	Diseases of Arteries, Arterioles, and Capillaries (n = 479)	Diseases of Veins and Lymphatics (n = 531)
Diagnosis ya
1997–1999	Reference	Reference	Reference	Reference	Reference
2000–2004	1.12b (0.87-1.42)	1.02b (0.80-1.30)	1.57b (0.64-3.87)	1.77b (1.14-2.75)	2.00b (1.35-2.97)
2005–2009	1.57b (1.25-1.97)	1.17b (0.93-1.47)	2.49b (1.07-5.76)	2.15b (1.42-3.26)	2.28b (1.56-3.34)
2010–2012	1.33b (1.05-1.68)	1.15b (0.91-1.46)	2.29b (0.97-5.45)	2.59b (1.70-3.96)	1.89b (1.27-2.81)
Age at diagnosis,c y
<40	Reference	Reference	Reference	Reference	Reference
40–65	2.22b (1.84-2.68)	1.31b (1.10-1.56)	2.92b (1.45-5.87)	1.34b (1.03-1.73)	1.91b (1.49-2.44)
≥65	4.29b (3.52-5.24)	2.53b (2.10-3.04)	7.75b (3.85-15.60)	2.72b (2.08-3.55)	2.23b (1.70-2.92)
Sex
Female	Reference	Reference	Reference	Reference	Reference
Male	1.84 (1.61-2.09)	1.43 (1.24-1.65)	2.00 (1.38-2.89)	1.62 (1.33-1.97)	1.37 (1.13-1.66)
BMI at baseline,d kg/m2
<18	0.91 (0.40-2.04)	1.30 (0.73-2.31)	1.46 (0.20-10.75)	1.25 (0.51-3.06)	1.25 (0.51-3.06)
18–24.9	Reference	Reference	Reference	Reference	Reference
25–29.9	1.55 (1.34-1.80)	1.20 (1.03-1.40)	1.27 (0.83-1.94)	1.25 (1.01-1.55)	0.91 (0.73-1.12)
≥30	1.97 (1.68-2.30)	1.53 (1.30-1.80)	1.07 (0.66-1.74)	1.33 (1.05-1.69)	1.30 (1.05-1.61)

Data presented as HR (95% CI).

^aAdjusted for age at diagnosis, BMI at baseline, and CCI score.

^bFor the models that violated proportional hazards assumptions, we used Cox models with cubic splines.

^cAdjusted for diagnosis y, race, sex, BMI at baseline, and CCI score.

^dAdjusted for diagnosis y, age at diagnosis, race, sex, and CCI score.