Table 4.
Clinical Risk Factors For CVD Subgroup 1 to 5 Years After Cancer Diagnosis Among Thyroid Cancer Survivors (N = 3822)
| Variable | CVD Subgroup | ||||
|---|---|---|---|---|---|
| Hypertension (n = 1075) | Heart Disease (n = 968) | Cerebrovascular Disease (n = 125) | Diseases of Arteries, Arterioles, and Capillaries (n = 479) | Diseases of Veins and Lymphatics (n = 531) | |
| Cancer stage at diagnosisa | |||||
| Localized | Reference | Reference | Reference | Reference | Reference |
| Regional | 1.07 (0.92–1.23) | 0.97 (0.83–1.13) | 0.91 (0.59–1.42) | 1.07 (0.86–1.33) | 1.05 (0.86–1.29) |
| Distant | 1.32 (0.96–1.81) | 1.33 (0.95–1.87) | 0.45 (0.11–1.83) | 1.58 (1.01–2.46) | 1.24 (0.76–2.02) |
| Treatmentb | |||||
| Surgery only | Reference | Reference | Reference | Reference | Reference |
| Surgery and radiation | 0.99 (0.87–1.13) | 1.03 (0.90–1.18) | 1.44 (0.99–2.09) | 1.02 (0.84–1.24) | 0.98 (0.82–1.17) |
| Other | 0.66 (0.32–1.36) | 1.38 (0.99–1.92) | 1.38 (0.19–10.21) | 0.64 (0.20–2.06) | 0.99 (0.36–2.69) |
| TSH suppression therapyb | |||||
| No | Reference | Reference | Reference | Reference | Reference |
| Yes | 1.22c (1.06–1.41) | 1.13c (0.98–1.32) | 0.89c (0.58–1.35) | 1.27c (1.04–1.56) | 1.12c (0.91–1.36) |
| CCI score at baselined | |||||
| 0 | Reference | Reference | Reference | Reference | Reference |
| ≥1 | 6.78c (5.33–8.61) | 3.37c (2.78–4.08) | 4.48c (2.21–9.10) | 3.87c (2.87–5.20) | 7.45c (5.30–10.48) |
Data presented as HR (95% CI).
a
Adjusted for diagnosis y, age at diagnosis, race, sex, BMI at baseline, and CCI score.
b
Adjusted for diagnosis y, age at diagnosis, race, sex, BMI at baseline, cancer stage at diagnosis, and CCI score.
c
For the models that violated proportional hazards assumptions, we used Cox models with cubic splines.
d
Adjusted for diagnosis y, age at diagnosis, race, sex, and BMI at baseline.