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Correlation of mRNA levels with HbA1c and in vivo insulin secretion (HOMA2%B*) in LCM-cut islet tissue. The mRNA levels determined by Affymetrix array of LCM-isolated islet tissue (n = 18), HbA1c, fasting blood glucose, and in vivo insulin secretion of the same patients were assessed as described in Materials and Methods. Correlations of islet mRNAs with (A and B) insulin secretion expressed as HOMA2%B* or with (C–H) plasma HbA1c. *Adjusted for insulin resistance (HOMA2-IR).
