Comparison 6. Metformin versus laparoscopic ovarian drilling.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Live birth rate	1	120	Odds Ratio (M‐H, Fixed, 95% CI)	2.29 [1.09, 4.78]
2 Adverse events (gastrointestinal side effects)	2	230	Odds Ratio (M‐H, Fixed, 95% CI)	7.77 [2.43, 24.89]
2.1 Participants with BMI < 30kg/m2	1	120	Odds Ratio (M‐H, Fixed, 95% CI)	4.75 [1.27, 17.82]
2.2 Participants with BMI ≥ 30kg/m2	1	110	Odds Ratio (M‐H, Fixed, 95% CI)	25.62 [1.46, 449.07]
3 Clinical pregnancy rate	2	230	Odds Ratio (M‐H, Fixed, 95% CI)	0.93 [0.54, 1.59]
3.1 Participants with BMI < 30 kg/m2	1	120	Odds Ratio (M‐H, Fixed, 95% CI)	1.74 [0.83, 3.62]
3.2 Participants with BMI ≥ 30 kg/m2	1	110	Odds Ratio (M‐H, Fixed, 95% CI)	0.40 [0.17, 0.95]
4 Ovulation rate	1	145	Odds Ratio (M‐H, Fixed, 95% CI)	0.51 [0.26, 1.01]
5 Miscarriage rate per woman	2	230	Odds Ratio (M‐H, Fixed, 95% CI)	0.58 [0.23, 1.47]
5.1 Participants with BMI < 30 kg/m2	1	120	Odds Ratio (M‐H, Fixed, 95% CI)	0.63 [0.21, 1.89]
5.2 Participants with BMI ≥ 30 kg/m2	1	110	Odds Ratio (M‐H, Fixed, 95% CI)	0.48 [0.08, 2.74]
6 Sensitivity analysis: miscarriage rate per pregnancy	2	102	Odds Ratio (M‐H, Fixed, 95% CI)	0.55 [0.20, 1.48]
6.1 Participants with BMI < 30 kg/m2	1	70	Odds Ratio (M‐H, Fixed, 95% CI)	0.44 [0.14, 1.43]
6.2 Participants with BMI ≥ 30 kg/m2	1	32	Odds Ratio (M‐H, Fixed, 95% CI)	0.94 [0.14, 6.19]
7 Body mass index (kg/m2)	1	110	Mean Difference (IV, Fixed, 95% CI)	‐3.60 [‐13.48, 6.28]
8 Serum testosterone (nmol/L)	1	110	Mean Difference (IV, Fixed, 95% CI)	‐0.16 [‐1.09, 0.77]