Boudhraa 2010.

Methods	RCT Setting: Tunisia Method of randomisation: not stated* Blinding: unblinded Number randomised: 63
Participants	Summary: metformin vs CC in PCOS non‐obese women Inclusion criteria: unclear. ?diagnostic criteria of PCOS used Exclusion criteria: male factor infertility, tubal disease Baseline characteristics of each group: metformin vs CC mean age: 30.55, 30.72 mean BMI: 29.9, 29.7 Dropouts: none
Interventions	Main intervention: metformin 850 mg/d, CC 100 mg for 5 days Duration: not stated Co‐interventions: recommendations on healthy diet
Outcomes	Primary: live birth rate Secondary: clinical pregnancy, ovulation: method to confirm ovulation not stated, BMI
Notes	*Study protocol is too brief. Inadequate information to assess the quality of the study. No reply from study author
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Inadequate information
Allocation concealment (selection bias)	Unclear risk	Inadequate information
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Inadequate information
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Inadequate information
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Inadequate information
Selective reporting (reporting bias)	Unclear risk	Inadequate information
Other bias	Low risk	No evidence of other bias however, limited reported methodology