Table 1.

Regression analysis of epigenetic age acceleration of four brain tissues and blood from the London Brain Bank cohort [9] versus brain Braak stage and of two brain tissues from the Mount Sinai cohort [12] versus amyloid plaque levels

	London cohort		London cohort (age in model)		Mount Sinai cohort (age in model)
	Coefficient	P value	Coefficient	P value	Coefficient	P value
Prefrontal cortex	0.434	0.164	− 0.345	0.107	− 0.029	0.629
Entorhinal cortex	0.969	0.004	0.424	0.125	–	–
Sup. Temporal Gyrus	0.653	0.019	− 0.062	0.786	0.004	0.944
Cerebellum	1.127	0.002	− 0.059	0.788	–	–
Blood	− 0.278	0.632	− 0.090	0.870	–	–

Shown for each cohort the coefficient and P value for the regression analysis between age acceleration and Braak stages (London cohort) or amyloid plaque levels (Mount Sinai cohort) with chronological age as a covariate