Figure 7.

Two‐dimensional models and consequence on cell attachment. (a) Schematic of a parallel‐plate flow chamber (from Cooper et al., 2012) (b) Top: fluorescence microscopy images showing cells attached either predominantly flatly to collagen struts (left) or in a bridged manner (right). Bottom: schematic diagram of attachment morphologies with flatly attached cells on the left and bridged (either dual or multiattachment points) cells on the right. For both microscopy images and schematics, the collagen structure is depicted in red, and the cell cytoplasm is in green (from McCoy and O'Brien, 2010)