Fig. 7.

MSC-derived exosomal miR-133b suppressed tumor growth of glioma in vivo. a Tumorigenesis of nude mice (n = 6). b Tumor volume of nude mice (n = 6). c Tumor weight of nude mice (n = 6). d Expression of miR-133b and EZH2 determined using RT-qPCR. e Protein levels of EZH2, Wnt1, p-GSK-3β, GSK-3β, and β-catenin measured using Western blot analysis; ^#p < 0.05 vs. nude mice injected with exo-mimic NC; ^&p < 0.05 vs. glioma cells injected with exo-inhibitor NC; measurement data were shown as mean ± standard deviation; comparisons between two groups were conducted by unpaired t test; The data analysis at different time points was performed by repeated measures ANOVA with Bonferroni post hoc test. The experiment was repeated three times to obtain the mean value