Table 1.

Criteria that make considering renal replacement therapy (RRT) initiation at any time during the 2 stages of the study

Serum potassium concentration > 6 mmol/l

Serum potassium concentration > 5.5 mmol/l persisting despite medical treatment

Arterial blood pH < 7.15 in a context of pure metabolic acidosis (PaCO2 < 35 mmHg) or in a context of mixed acidosis with a PaCO2 > 50 mmHg without possibility of increasing alveolar ventilation

Acute pulmonary edema due to fluid overload despite diuretic therapy leading to severe hypoxemia requiring oxygen flow rate > 5 l/min to maintain SpO2 > 95% or FiO2 > 50% under invasive or non- invasive mechanical ventilation