Fig. 5.

Effects of Gdf11 gene transfer on high fat diet-induced obese mice. HFD-induced obese mice were injected with pLIVE-GDF11 or control plasmids and continued on HFD for 4 weeks. a Experiment schedule; b change of body weight after gene transfer; c histological images of EWAT (20 ×); d average diameter of adipocytes; e daily food intake; f accumulative food intake; g serum glucose level in GTT on day 23 after gene transfer; h area under the curve of GTT; i relative serum glucose concentrations in ITT on day 25 after gene transfer; j liver weight; k histological presentations of the liver sections (×10); l average diameter of vacuoles in hepatocytes in liver sections. Scale bars represent 100 µm. Each data point represents mean ± SEM (n = 5). *P < 0.05 comparing to mice injected with control plasmids