Table 1.

Timing of treatment visits and data collection

	Baseline	Treatment phase				Follow-up phase
	Day 0	Day 4	Day 7	Day 10	Day 14	Day 28	Day 42
	V1	V2	V3	V4	V5	V6	V7
Sign informed consent	×
Randomization	×
Medical history	×
Intervention	×	×	×	×
Primary outcome
CAT	×				×	×	×
Secondary outcomes
Treatment failure		×	×	×	×
Length of hospital stays					×
Readmission due to AECOPD						×	×
Intubation rate		×	×	×	×	×	×
Mortality		×	×	×	×	×	×
mMRC	×	×	×	×	×	×	×
SF-36	×				×	×	×
COPD-PRO	×				×	×	×