Table 6.

The results of ROC curve analysis (a: Youden index, b: Significance Level P (Area = 0.5), Estimate criterion: optimal cut-off point for gene expression)

	Estimate criterion	AUC	Ja	Sensitivity	Specificity	P-valueb
SOCS1	≤ 1.5	0.65	0.26	62	64	0.005
SOCS2	≤ 1.3	0.78	0.46	84	62	<  0.0001
SOCS3	≤ 1.3	0.72	0.32	72	60	<  0.0001
SOCS5	≤ 0.3	0.92	0.74	90	84	<  0.0001
Combination of four genes	>  0.54	0.93	0.8	88	92	<  0.0001