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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Drug Alcohol Depend. 2019 Jan 4;195:140–147. doi: 10.1016/j.drugalcdep.2018.12.006

Fig. 3:

Fig. 3:

HR (A) and BP (C) following escalating doses of MDPV in male and female rats. HR (E) and BP (G) dose-effects following MDPV and cocaine administration in male rats. These data show average daytime MDPV-induced effects (8 h mean ± SD, n=6–7). The ED50 values (mg/kg; mean ± SD) for cardiovascular effects of MDPV in males (HR:2.4 ± 0.3; BP:2.6 ± 0.4) was not significantly different from females (HR: 3.3 ± 0.3; BP: 3.4 ± 0.2) (A, C), but was significantly different from cocaine (HR:12.7 ±1.5; BP: 14.9 ± 0.8). The * in plot 3F indicates cocaine treatment was significant different from MDPV treatment (p<0.05). The MDPV data for male rats in A and C are repeated in plots E and G for direct comparison with cocaine in male rats.