Fig. 4.

CircABCB10 up-regulated HMG20A expression by sponge miR-670-3p. a Putative binding sites for miR-670-3p and HMG20A 3′-UTR. b Analysis of luciferase activity in PC9 and A549 cells co-transfected with miR-670-3p mimic and pmirgLO HMG20A3′-UTR-WT or pmirgLO-HMG20A 3′-UTR-Mut vector. P < 0.01 by t-test. c mRNA expression levels of E2F5 in different groups. d Protein expression levels of E2F5 in different groups. P < 0.05 and P < 0.01 by ANOVA. e Spearman correlation analysis of circABCB10 and E2F5 in non-small cell lung cancer tissues (n = 40) (Spearman r = − 0.3915; P < 0.01).* vs control group, #vs miR-670-3p mimics group.**P < 0.01, ^#P < 0.05