Table 3.

Differences in Risk of Malignancy Between Sonographic Patterns

	Comparison		NIFTP cancer		NIFTP benign
	Pattern 1	Pattern 2	OR [CI]	p-Value	OR [CI]	p-Value
All ITNs	Very low	Low/intermediate	NA	0.01	NA	0.15
	Very low	High	NA	<0.001	NA	<0.001
	Very low	Non-ATA	NA	<0.001	NA	0.005
	Low/intermediate	High	5.18 [2.34–11.6]	<0.001	7.36 [3.16–17.25]	<0.001
	Low/intermediate	Non-ATA	2.35 [1.46–3.80]	<0.001	2.24 [1.25–4.10]	0.005
	High	Non-ATA	0.45 [0.20–0.99]	0.04	0.30 [0.13–0.69]	0.003
AUS/FLUS	Very low	Low/intermediate	NA	0.06	NA	0.19
	Very low	High	NA	<0.001	NA	<0.001
	Very low	Non-ATA	NA	0.001	NA	0.03
	Low/intermediate	High	10.75 [2.84–47.30]	<0.001	16.93 [4.20–80.21]	<0.001
	Low/intermediate	Non-ATA	2.52 [1.07–6.24]	0.03	1.79 [0.62–5.47]	0.24
	High	Non-ATA	0.23 [0.06–0.83]	0.02	0.10 [0.02–0.40]	<0.001
FN/HCN	Very low	Low/intermediate	NA	0.58	NA	>0.99
	Very low	High	NA	0.26	NA	0.54
	Very low	Non-ATA	NA	0.29	NA	0.57
	Low/intermediate	High	3.12 [1.05, 9.10]	0.02	3.57 [0.99–11.65]	0.03
	Low/intermediate	Non-ATA	2.33 [1.30, 4.23]	0.003	2.54 [1.23–5.38]	0.008
	High	Non-ATA	0.75 [0.25, 2.24]	0.62	0.71 [0.22–2.51]	0.57

Because no cancers were detected in the very low suspicion pattern, odds ratios could not be calculated for comparisons with this group. The low and intermediate sonographic patterns were grouped for comparisons with other patterns because their rates of malignancy were not significantly different.

CI, confidence interval; ITNs, cytologically indeterminate thyroid nodules (both AUS/FLUS and FN/HCN); Low/intermediate, low/intermediate suspicion sonographic patterns; NA, not applicable; NIFTP, noninvasive follicular thyroid neoplasm with papillary-like nuclear features; OR, odds ratio.