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. 2018 Nov 15;24(11):637–644. doi: 10.1089/ten.tec.2018.0249

FIG. 3.

FIG. 3.

Detection of miR-133a-3p after intraperitoneal injection into mice. (A) Determining the amount of miR-133a-3p-enriched EV needed to increase circulating miR-133a-3p. Blood was collected 4 h after injection. ** and *** indicate p < 0.01 and p < 0.0001 compared with the group injected with EVs from NT control cells (Tukey's multiple comparison test after ANOVA). (B) Examine the duration of injected miR-133a-3p-enriched EV in circulation. The amount of EV injected per mouse was 200 μg protein. *** p < 0.0001 compared with the group injected with EVs from NT control cells (Bonferroni post-tests after ANOVA). NT, nontargeting.