Table 1.
Results for the bla genotype, MLST, MICs, MBCs, and FICIs of colistin, meropenem, and amikacin against CRKP isolates.
| Isolate | Source | bla genotype | MLST | MIC (μg/ml) | MBC | FICI | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| COL | MEM | AMK | COL | MEM | AMK | COL+MEM | COL+AMK | ||||
| 700603 | 4 | 1/4 | 1/2 | ||||||||
| CRKP1 | Sputum | KPC-2, SHV, TEM, CTX-M-15 | ST76 | 8 | 64 | 8 | 0.25 | 1 | |||
| CRKP2 | Sputum | KPC-2, SHV, TEM, CTX-M-15 | ST76 | 8 | 128 | 4 | 0.25 | 0.375 | |||
| CRKP3 | Sputum | KPC-2, SHV, TEM, CTX-M-15 | ST76 | 8 | 128 | 8 | 0.25 | 0.75 | |||
| CRKP4 | Sputum | KPC-2, SHV, TEM, CTX-M-15 | ST76 | 16 | 16 | 8 | 0.375 | 0.625 | |||
| CRKP5 | Sputum | KPC-2, SHV, TEM, CTX-M-15 | ST76 | 8 | 16 | 8 | 0.375 | 0.75 | |||
| CRKP6 | Sputum | KPC-2, SHV, TEM, CTX-M-15 | ST76 | 16 | 16 | 8 | 0.375 | 0.625 | |||
| CRKP7 | Sputum | KPC-2, SHV, TEM, CTX-M-15 | ST76 | 8 | 16 | 8 | 1 | 0.25 | |||
| CRKP8 | Sputum | KPC-2, SHV, TEM, CTX-M-15 | ST76 | 8 | 16 | 4 | 0.625 | 0.375 | |||
| CRKP9 | Sputum | KPC-2, SHV, TEM, CTX-M-15 | ST76 | 8 | 16 | 4 | 0.625 | 0.375 | |||
| CRKP10 | Sputum | KPC-2, SHV, TEM, CTX-M-15 | ST76 | 8 | 16 | 8 | 0.5 | 0.25 | |||
| CRKP11 | Sputum | KPC-2, SHV, CTX-M-15 | ST76 | 8 | 16 | 16 | 0.5 | 0.375 | |||
| CRKP12 | Sputum | KPC-2, NDM-5, SHV, TEM, CTX-M-177 | ST76 | 8 | 64 | 2 | 2× | 1× | 2× | 0.375 | 0.375 |
| CRKP13 | Blood | KPC-2, SHV, TEM, CTX-M-15 | ST76 | 4 | 16 | 4 | 1× | 1× | 1× | 0.75 | 0.25 |
| CRKP14 | Blood | KPC-2, SHV, TEM, CTX-M-15 | ST76 | 4 | 16 | 2 | 1× | 1× | 1× | 0.75 | 0.375 |
| CRKP15 | Blood | KPC-2, SHV, TEM, CTX-M-15 | ST76 | 4 | 64 | 2 | 2× | 1× | 1× | 0.375 | 1 |
| CRKP16 | Sputum | KPC-2, SHV, TEM, CTX-M-15 | ST76 | 16 | 16 | 8 | 0.25 | 0.625 | |||
| CRKP17 | Sputum | KPC-2, SHV, TEM, CTX-M-15 | ST76 | 16 | 16 | 8 | 0.375 | 0.625 | |||
| CRKP18 | Sputum | KPC-2, SHV, TEM, CTX-M-15 | ST76 | 16 | 16 | 16 | 0.375 | 0.25 | |||
| CRKP19 | Sputum | KPC-2, SHV, TEM, CTX-M-15 | ST76 | 2 | 64 | 2 | 1× | 1× | 2× | 0.375 | 0.75 |
| CRKP20 | Sputum | KPC-2, SHV, TEM, CTX-M-15 | ST76 | 4 | 16 | 2 | 2× | 2× | 2× | 0.75 | 0.625 |
| CRKP21 | Secretion | KPC-2, SHV, TEM, CTX-M-15 | ST76 | 4 | 8 | 4 | 0.25 | 0.375 | |||
| CRKP22 | Sputum | KPC-2, SHV, TEM, CTX-M-15 | ST76 | 8 | 8 | 8 | 0.625 | 0.375 | |||
| CRKP23 | Sputum | KPC-2, SHV, TEM, CTX-M-15 | ST76 | 8 | 16 | 4 | 0.5 | 0.375 | |||
| CRKP24 | Blood | KPC-2, SHV | ST11 | 4 | 128 | 1 | 1× | 2× | 2× | 0.625 | 0.375 |
| CRKP25 | Sputum | KPC-2, SHV, TEM, CTX-M-15 | ST76 | 8 | 16 | 2 | 1× | 2× | 1× | 0.5 | 1 |
| CRKP26 | Blood | KPC-2, SHV, TEM, CTX-M-15 | ST76 | 32 | 32 | 8 | 0.25 | 0.375 | |||
| CRKP27 | Sputum | KPC-2, TEM, CTX-M-15 | ST76 | 8 | 32 | 4 | 0.25 | 0.375 | |||
| CRKP28 | Sputum | KPC-2, TEM, CTX-M-15 | ST76 | 8 | 16 | 4 | 0.5 | 0.375 | |||
| CRKP29 | Sputum | KPC-2, SHV, TEM, CTX-M-15 | ST76 | 16 | 8 | 4 | 0.375 | 0.375 | |||
| CRKP30 | Sputum | KPC-2, SHV, TEM, CTX-M-15 | ST76 | 8 | 8 | 4 | 0.75 | 0.375 | |||
| CRKP31 | Sputum | SHV, TEM, CTX-M-15 | ST76 | 8 | 16 | 4 | 0.75 | 0.375 | |||
| CRKP32 | Sputum | KPC-2, SHV, TEM, CTX-M-15 | ST375 | 2 | 8 | 1 | 1× | 1× | 1× | 1 | 0.625 |
| CRKP33 | other specimens | KPC-2, SHV, TEM, CTX-M-15 | ST76 | 8 | 16 | 4 | 0.5 | 0.5 | |||
| CRKP34 | Sputum | SHV, TEM | ST530 | 2 | 4 | 1 | 1× | 1× | 1× | 1 | 0.625 |
| CRKP35 | Sputum | SHV, TEM | ST3335 | 8 | 4 | 4 | 0.75 | 0.375 | |||
| CRKP36 | Blood | KPC-2, SHV, TEM, CTX-M-177 | ST11 | 8 | 256 | 16,384 | 0.625 | – | |||
| CRKP37 | Sputum | KPC-2, SHV, TEM, CTX-M-15, CTX-M-177 | ST290 | 8 | 16 | 2 | 0.375 | 0.25 | |||
| CRKP38 | Sputum | KPC-2, SHV, TEM, CTX-M-15, CTX-M-177 | ST290 | 8 | 16 | 2 | 0.375 | 0.25 | |||
| CRKP39 | Sputum | KPC-2, SHV, TEM, CTX-M-15, CTX-M-177 | ST290 | 8 | 16 | 2 | 0.375 | 0.25 | |||
| CRKP40 | Sputum | KPC-2, NDM-1, SHV, TEM, CTX-M-15, CTX-M-177 | ST290 | 8 | 128 | 1 | 0.25 | 0.375 | |||
MLST, multilocus sequence typing; MIC, minimum inhibitory concentrations; MBC, minimum bactericidal concentration; FICI, fractional inhibitory concentration index; COL, colistin; MEM, meropenem; AMK, amikacin; –, not tested.