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. 2019 Dec 10;10:2830. doi: 10.3389/fmicb.2019.02830

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Copyright © 2019 Bai, Lin, Li, Zhou, Liu, Zhong, Wu, Jiang, Du, Yang, Xie and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cleavage activity of crRNA-guided LbCas12a. M: DL15000 DNA marker; 1: intact linearized target dsDNA (4618 bp); 2: cleavage products from linearized target dsDNA; 3: intact linearized non-target dsDNA (2966 bp); 4: linearized non-target dsDNA after cleavage reaction. dsDNA binding to the LbCas12a-crRNA complex is marked by a red triangle where the band can be seen to shift upward compared with the intact linearized dsDNA. The expected cleavage products are marked by red arrows.