Figure 11.

A schematic representation of the main cytoskeletal proteins associated with skeletal muscle. The dystrophin‐associated protein complex (DAPC) is a group of sarcoplasmic (α‐dystrobrevin, syntrophins, and nNOS), transmembrane (β‐dystroglycan, sarcoglycans, caveolin‐3, and sarcospan) and extracellular proteins (α‐dystroglycan and laminin), linking dystrophin to the extracellular matrix (ECM). Dystrophin also links to desmin, an important sarcolemma integrity protein, via the α‐dystrobrevin‐syncoilin interaction, providing a strong mechanical link between the intracellular cytoskeleton and the extracellular matrix