Figure 15.

Schematic representation of the key signaling molecules in immunometabolism. The cross‐talk between metabolic and inflammatory signaling pathways occurs at multiple levels (inter‐ and intra‐tissue/organ). Several of the above shown factors are part of the skeletal muscle secretome (myokines; adipomyokines) such as IL‐15 a regulator of muscle adiposity, IL‐6 crucial for inflammation and glucose homeostasis; and several fat/ glucose metabolic genes (AMPK, FGF21, IGF1,PGC1α, Irisin) that play a pivotal role in maintaining the immunometabolic profile of skeletal muscle