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. 2019 Jul 26;45(6):944–949. doi: 10.1002/biof.1547

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© 2019 The Authors. BioFactors published by Wiley Periodicals, Inc. on behalf of International Union of Biochemistry and Molecular Biology.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Inhibition of STC1 in HaCaT cells reduces the negative influence of HaCaT cells on matrix‐related gene expression of dermal fibroblasts in the coculture model. (a) Dermal fibroblasts were cocultured with or without HaCaT cells in Transwells. After 2 days of coculture, the abundance of (b) MMP1, (c) collagen1A1, and (d) elastin mRNAs in dermal fibroblasts was negatively influenced (Cont) compared with fibroblasts alone (blank). The changes were significantly ameliorated in dermal fibroblasts cocultured with HaCaT cells transfected with siRNA for STC1 (STC) compared with dermal fibroblasts cocultured with HaCaT cells transfected with negative control siRNA (Nega). The statistical significance of differences between groups was determined by Dunnett's test. ***: p < .001 (STC) versus (Nega)