Table 1.
Frequency distribution of genotypes/allele in the study groups
|
a. Genotype (VF variants) 526 T/G (V176F) |
HIV infected N = 63(%) |
HC N = 67(%) |
HIV infected vs HC | |
| p value | OR (95% CI) | |||
| TT(F/F) | 19 (30.16) | 23 (34.33) | 1.00 | Reference |
| TG(V/F) | 36 (57.14) | 34 (50.75) | 0.56 | 0.78 (0.36–1.68) |
| GG(V/V) | 08 (12.70) | 10 (14.93) | 1.00 | 1.03 (0.34–3.14) |
| Allele (V176F) |
HIV infected N = 126(%) |
HC N = 134(%) |
HIV infected vs HC | |
| p value | OR (95% CI) | |||
| T(F) | 74 (58.73) | 80 (59.70) | 1.00 | Reference |
| G(V) | 52 (41.27) | 54 (40.30) | 0.90 | 1.04 (0.63–1.71) |
|
b. Genotype (YH variants) 428 T/C (Y158H) |
HIV infected N = 63(%) |
HC N = 67(%) |
HIV infected vs HC | |
| p value | OR (95% CI) | |||
| TT(Y/Y) | 48 (76.19) | 23 (34.33) | 1.00 | Reference |
| TC(Y/H) | 15 (23.81) | 44 (65.67) | < 0.0001 | 0.16 (0.07–0.35) |
| CC(H/H) | 0 (0) | 0 (0) | – | – |
| Allele (Y158H) |
HIV infected N = 126(%) |
HC N = 134(%) |
HIV infected vs HC | |
| p value | OR (95% CI) | |||
| T(Y) | 111 (88.10) | 90 (67.16) | 1.00 | Reference |
| C(H) | 15 (11.90) | 44 (32.84) | < 0.0001 | 3.62 (1.89–6.92) |
a: Frequency distribution of V176F and Y158H polymorphisms in HIV infected vs HIV uninfected healthy control groups. Presence of TT (F/F) for TG (V/F), GG (V/V) genotypes, T for G allele was taken as reference group for statistical analysis
b: Frequency distribution of Y158H polymorphism in HIV infected vs healthy control groups. Presence of TT (Y/Y) for TC (Y/H), CC (H/H) genotypes, T for C allele was taken as reference group for statistical analysis
Fisher’s exact test was applied. N = number of subjects; (%) = frequency of genotypes/alleles, OR = Odds ratio; CI = Confidence Interval. The results with significance are shown in bold