Figure 1.

The influence of NK cell education via KIR2DL1 (2DL1) and KIR2DL2/3 (2DL2/3) on the frequency of granzyme B positive (%GzB⁺) target cells generated in the ADCC‐GTL assay. (A) The %GzB⁺ cells generated by PBMC from 2DL1⁺ individuals co‐expressing HLA‐C2 (i.e., educated) or not (i.e., uneducated HLA‐C1 homozygotes). (B) The %GzB⁺ cells generated by PBMC from 2DL2/3⁺ individuals co‐expressing HLA‐C1 (i.e., educated) or not (i.e., uneducated, HLA‐C2 homozygotes,). (C) The %GzB⁺ cells generated by PBMC from individuals expressing the 3 possible HLA‐C genotypes. C2* = both homozygotes and heterozygotes for C2; C1* = both homozygotes and heterozygotes for C1. The results presented in this figure are a re‐analysis of data previously published in reference 42