Table 1.
Study population HLA allotypes and presence of KIR2DL1, KIR2DL2, KIR2DS2, KIR2DL3, and KIR3DL1 genes
| Bw4/62 | C1/C2 | HLA‐A | HLA‐B | HLA‐C | 2DL1 | 2DL2 | 2DS2 | 2DL3 | 3DL1 | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2 a | Bw4b | C1/C2c | 02:01 | 24:02 | 44:02 | 51:01 | 05 | 08 | +d | + | + | + | + |
| 3 | Bw4/6 | C1/C2 | 02:01 | 31:01 | 27:01 | 40:01 | 03:02 | 15:02 | + | ‐ | ‐ | + | + |
| 5 e | Bw4/6 | C1/C2 | 02:01 | 02:01 | 08:01 | 44:02 | 01:01 | 04:01 | + | ‐ | ‐ | + | + |
| 6 f | Bw4 | C1/C2 | 31:01 | 68:01 | 27:08 | 51:01 | 02:02 | 12:03 | + | ‐ | ‐ | * | + |
| 12 e | Bw4/6 | C1/C1 | 01:01 | 23:01 | 14:01 | 38:05 | 08:02 | 12:03 | + | ‐ | ‐ | + | + |
| 21 f | Bw4/6 | C2/C2 | 02:01 | 02:01 | 07:02 | 57:01 | 05 | 06:02 | + | ‐ | ‐ | + | + |
| 23 | Bw6 | C1/C1 | 02:01 | 02:01 | 18:01 | 40:01 | 03:04 | 07:01 | + | ‐ | ‐ | + | + |
| 29 | Bw6 | C1/C1 | 02:01 | 02:01 | 07:02 | 08:01 | 07 | 07 | + | + | + | + | + |
| 30 f | Bw6 | C1/C2 | 02:01 | 30:02 | 07:02 | 35:01 | 04:01 | 07:02 | + | ‐ | ‐ | + | + |
| 31 | Bw6 | C1/C1 | 02:01 | 03:01 | 07:02 | 40:01 | 03:02 | 07:10 | + | + | + | + | + |
| 32 f | Bw6 | C1/C2 | 03:01 | 11:01 | 07:02 | 35:01 | 04:01 | 07:02 | + | ‐ | ‐ | + | + |
| 38 | Bw6 | C1/C2 | 02:01 | 33:03 | 15:01 | 35:08 | 03:03 | 04:01 | + | + | + | + | + |
| 34 | Bw6 | C1/C1 | 01:01 | 02:01 | 08:01 | 40:01 | 03:02 | 07:01 | + | + | + | + | + |
| 44 | Bw4/6 | C2/C2 | 01:01 | 02:01 | 15:01 | 57:01 | 05 | 06:02 | + | + | ‐ | + | + |
| 45 | Bw4 | C1/C2 | 01:01 | 02:01 | 38:01 | 57:01 | 06:02 | 12:03 | + | ‐ | ‐ | + | + |
| 48 | Bw4/6 | C1/C2 | 01:01 | 03:01 | 14:02 | 57:01 | 06:02 | 08:02 | + | + | + | + | + |
| 49 | Bw4 | C1/C2 | 01:01 | 26:01 | 38:01 | 57:01 | 06:02 | 12:03 | + | ‐ | ‐ | + | + |
| 50 | Bw4 | C2/C2 | 02:02 | 30:02 | 53:01 | 57:03 | 04:01 | 18 | + | + | + | + | + |
| 51 | Bw4/6 | C2/C2 | 01:01 | 68:02 | 18:01 | 57:01 | 05:01 | 06:02 | + | + | + | + | + |
| 52 e | Bw6 | C2/C2 | 02:01 | 02:01 | 35 | 40 | 04:01 | 04:01 | + | ‐ | ‐ | + | ‐ |
| 53 e | Bw6 | C1/C1 | 03:01 | 03:01 | 18:01 | 35 | 03:03 | 16:01 | + | ‐ | ‐ | + | ‐ |
| 54 e | Bw4/6 | C1/C1 | 02:01 | 24:02 | 39:01 | 51:01 | 07:02 | 07:02 | + | ‐ | ‐ | + | ‐ |
Subject codes from #2 through #50 are the same as those used in Table S1.
Bw4 = Bw4 homozygote, Bw6 = Bw6 homozygote with no Bw4 at the HLA‐A locus, Bw4/6 = carriers of a Bw4 and Bw6 allele.
C1/C1 = HLA‐C1 group homozygotes, C2/C2 = HLA‐C2 group homozygotes, C1/C2 = carriers of both a C1 and C2 group allotype.
“‐” = absent; “+” = present.
Subjects contributing PBMC used to isolate single positive inhibitory NK receptor positive (SPiNKR+) NK cells for use as effector cells for ADCC‐GranToxuLux (ADCC‐GTL) assays only.
Subjects contributing PBMC used in both antibody‐dependent NK cell activation assays and to isolate SPiNKR+ for use as effector cells for ADCC‐GTL assays.