Table 9.

Interventions to treat fatigue in PD

Intervention
Drug class/intervention strategy	Drug/intervention	Efficacy	Safety	Practice implications
Monoamine oxidase B (MAO‐B) inhibitors	Rasagiline	Efficacious	Acceptable risk without specialized monitoring	Possibly useful
Psychoactive drugs	Methylphenidate	Insufficient evidence	Insufficient evidence	Investigational
	Modafinil	Insufficient evidence	Insufficient evidencea	Investigational
Nonpharmacological interventions	Acupuncture	Insufficient evidence	Acceptable risk without specialized monitoring	Investigational

^aSee Table 7.