Skip to main content
. 2019 Oct 30;58(50):18252–18256. doi: 10.1002/anie.201911315

Figure 4.

Figure 4

Gatekeeping of KS domain controls module skipping in luteoreticulin biosynthesis. A) Workflow to generate the aAT4 mutant (S. albus::pHY145). B) Amino acid sequences of original and mutated sites (introduced by restriction enzyme HpaI). C) HPLC profiles of (i) aureothin reference (1), (ii) luteoreticulin reference (2), and (iii) metaboilites of KR2 null+aAT4 mutant. UV detection is at 350 nm. D) Module skipping is not influenced by AT4 activity.