Figure 5.

Effects of senktide administered centrally for 4 days on the subsequent secretion of dynorphin (DYN), gonadotrophin‐releasing hormone (GnRH) and Kp from medial basal hypothalamus (MBH) tissues incubated in vitro. A, The suppressed release of DYN in the animals that received a daily third ventricular (3V) injection of senktide compared to the saline‐injected control animals. B, The elevated secretion of GnRH in the senktide‐treated animals compared to the saline‐injected control animals. C, Senktide administration was ineffective at inducing Kp secretion in the senktide‐treated animals compared to the saline‐injected control animals. The number of animals represented is shown within each bar. Bars represent the mean ± SEM. Open bars, saline controls; hatched bars, senktide‐treated. An unpaired t test was used to compare control vs senktide‐treated animal groups: *P < 0.05, **P < 0.01