Table 1.
The comparison of PD-1 inhibitors and chemotherapy.
| Trial | Drug | PD-L1 CPS | ORR (%) | DOR (mo) | PFS (mo) | OS (mo) | AEs (%) | AE ≥Grade 3 (%) |
|---|---|---|---|---|---|---|---|---|
| <1 | 2 vs 10.4 | NA | NA | 4.8 vs 8.2 | ||||
| KEYNOTE-061 | Pembro vs Chemo | ≥1 | 16 vs 14 | 8 vs 5.2 | 1.5 vs 4.1 | 9.1 vs 8.3 | 53 vs 84 | 14 vs 35 |
| ≥10 | 24.5 vs 9.1 | NA | NA | 10.4 vs 8 | ||||
| KEYNOTE-062 | Pembro vs Chemo | ≥1 | 14.5 vs 36.8 | NA | 2 vs 6.4 | 10.6 vs 11.1 | 54.3 vs 91.8 | 17 vs 69 |
| ≥10 | 25 vs 36.7 | NA | 2.9 vs 6.1 | 17.4 vs 10.8 | ||||
| KEYNOTE-181 | Pembro vs Chemo | All comer | 13.1 vs 6.7 | 8.5 vs 10.7 | 2.1 vs 3.4 | 7.1 vs 7.1 | 64.3 vs 86.1 | 18.2 vs 40.9 |
| ≥10 | 21.5 vs 6.1 | 9.3 vs 7.7 | 2.6 vs 3 | 9.3 vs 6.7 |