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. 2019 Dec 10;13:1318. doi: 10.3389/fnins.2019.01318

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Copyright © 2019 Rodriguez-Morilla, Estivill, Estivill-Domènech, Albares, Segarra, Correa, Campos, Rol and Madrid.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ROC curves for healthy controls (A), insomnia (B), and DSPD (C). (D) The graphical representation of the confusion matrix data, as a function of the attributes TAP-RA (ranging from 0 to 1, Y-axis) and TAP-L5h (time of day, X-axis). Solid dots indicate true positives, and empty dots indicate false negatives. Cases classified as DSPD (green dots) were characterized by later mid-sleep time (TAP-L5h) than the other classes, while their TAP-RA scored within a wide range. Insomnia (red dots) exhibited a mid-sleep time between 3:00 and 5:00 h and, as in the case of DSPD, a wide range of TAP-RA scores. Healthy controls showed a mid-sleep time primarily centered around 4:00 h and predominantly high values of TAP-RA (0.65–0.7).