Table 4.
Compound |
ka (M−1s−1) |
kd (s−1) |
KD (μM) |
t1/2 (s) |
---|---|---|---|---|
8 | (5.62 ± 0.01) × 106 | 28.1 ± 0.09 | 5.00 ± 0.02 | 0.02 |
9 | (4.56 ± 0.09) × 105 | 0.0106 ± 0.00002 | 0.0234 ± 0.0005 | 65.2 |
15 | (6.00 ± 1) × 103 | 0.362 ± 0.002 | 60.0 ± 10 | 1.91 |
16 | (2.55 ± 0.07) × 104 | (6.49 ± 0.01) × 103 | 0.233 | 114 |