Fig. 7.

Effects of Cl-EE on circulatory proinflammatory cytokines levels in LPS-induced endotoxemia mice (n = 8). Mice received (75, 150 and 300 mg/kg, i.p.) Cl-EE 0.5 h before LPS stimulation (1 mg/kg, i.v.). Three hours after LPS challenge, whole blood was collected. The levels of a TNF-α, b IL-6 and c MCP-1 in serum were measured by ELISA. ^##P < 0.01 versus NC group; ^*P < 0.05 and ^**P < 0.01 versus LPS alone