Table 1.

Evidence suggesting the beneficial effects of MSCs on the AKI-CKD transition

References	Year	Animal	Model	Renal outcomes
Zhu et al. [84]	2017	Mice	Unilateral I/R injury	↓Fibrosis; ↑kidney weight and size; ↓α-SMA and collagen-I; ↓TGF-β1/Smad3
Masoud et al. [85]	2012	Rats	Unilateral I/R injury	↓Fibrosis
Semedo et al. [86]	2010	Mice	Unilateral I/R injury	↓Fibrosis; ↓proteinuria; ↑renal areas; ↓a-SMA, vimentin, and FSP-1
Gatti et al. [88]	2011	Rats	Unilateral I/R injury with contralateral nephrectomy	↑Renal function; ↓fibrosis; ↓proteinuria
Du et al. [90]	2012	Rats	Unilateral I/R injury with contralateral nephrectomy	↑Renal function; ↓fibrosis
Zou et al. [89]	2014	Rats	Unilateral I/R injury with contralateral nephrectomy	↑Renal function; ↓fibrosis; ↓α-SMA
Alfarano et al. [91]	2012	Rats	Unilateral I/R injury with contralateral nephrectomy	↑Renal function; ↓fibrosis and tubular dilation; ↓α-SMA and MMP2
Zhou et al. [93]	2016	Rats	Unilateral I/R injury with contralateral nephrectomy	↑Renal function; ↓fibrosis; ↓α-SMA; ↓microvascular rarefaction
Tögel et al. [94]	2009	Rats	Bilateral I/R injury	↑Renal function; ↓fibrosis; ↓PAI-1 and TGF-β
Du et al. [96]	2013	Rats	Bilateral I/R injury	↓Fibrosis
Rodrigues et al. [97]	2017	Rats	Bilateral I/R injury	↑Renal function; ↓FENa; ↓urinary concentrating defect; ↓renal damage score; ↓senescence

I/R ischemia/reperfusion, α-SMA α-smooth muscle actin, MMP2 matrix metalloproteinase 2, FSP-1 fibroblast specific protein-1, PAI-1 plasminogen activator inhibitor-1