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. 2019 Oct 18;294(50):19246–19254. doi: 10.1074/jbc.RA119.008234

Figure 5.

Figure 5.

The activation mechanism of 3-α-DOG on GPR56. A, AmpC β-lactamase inhibition response curve with different concentrations of 3-α-DOG. B, critical aggregation concentration curve for 3-α-DOG by dynamic light scattering assay. C, 3-α-DOG inhibits P19 responses. SRE–luciferase reporter assay responses were normalized to the maximal P19 response in the absence of 3-α-DOG. Data are presented as mean ± S.D.; n = 3; ****, p < 0.0001; two-tailed Student's t test. D, summary of 3-α-DOG (orange triangle) activity on various truncated GPR56 7TM receptor (42). The seven-amino-acid Stachel is depicted as seven solid green circles (each represents one amino acid).