Figure 5.

Comparison of the proteins copurified with Rrp6 and Rrp43 that showed increased levels upon depletion of Nop53. A, Venn diagram depicting the identified proteins in at least two replicates coimmunoprecipitated with Rrp6 and Rrp43, whose levels were increased upon depletion of Nop53. B, schematics of pre-40S and pre-60S maturation pathways, depicting stages at which the identified proteins copurified with Rrp6 or Rrp43 associate with pre-ribosomes. Classification was based on Ref. 29. Proteins not classified are as follows: pre-40S proteins Rpa49 and Rpc19; pre-60S proteins Jip5 and Rrp12. No common proteins had their levels reduced upon depletion of Nop53.