Figure 7.

Modification of HDL by ONE renders HDL no longer protective against LPS-stimulated inflammatory cytokine expression. HDL isolated from normal healthy subjects by DGUC was subjected to ex vivo modification of ONE. Thioglycollate-elicited peritoneal murine macrophages were treated with LPS along with ONE modified HDL for 4 h. Results from three individual experiments with 3–4 wells per treatment are plotted as mean ± S.D. Statistical significance was determined by one-way ANOVA with Dunnett's multiple comparisons compared with LPS + HDL (control). *, p < 0.05; **, p < 0.01.