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Disruption of compartmentalized protein localization in Cep290rd16/rd16 mice. Localization of outer segment-resident proteins (PRPH2 (A), RHO (B and D), ROM1 (C), ABCA4 (E), GUCY2D (F), ATP8A2 (G), PDE6B (H), and CNGA1 (H); all in red except CNGA1, which is in green) and inner segment membrane proteins (STX3 (A), STXBP1 (B), SNAP25 (C), IMPG2 (D), VAMP2 (E), ATP1A3 (F), and HCN1 (G); all in green) was examined by indirect immunofluorescence microscopy. Scale bar represents 25 μm.
