Table 3.
Growth, feeding problems, and other health issues according to genotype
| Deletion | Non‐deletion | Total | |
|---|---|---|---|
| N | 62 | 38 | 100 |
| UPD | 16 | ||
| IC | 4 | ||
| UBE3A | 18 | ||
| Head circumferencea, mean in SDS (SD) (n = 90)** | −1.67 (1.0) | −1.08 (0.93) | −1.44 (1.02) |
| Head circumference ≤−2 SDS at the age of 2 years or older, n (% of genetic subgroup) (n = 83) | 15 (30) | 5 (15) | 20 (24) |
| Height, mean SDS (SD) (n = 86) | −1.1 (1.1) | −0.86 (1.1) | −0.98 (1.1) |
| UPD | −0.7 (1.4) | ||
| IC | −1.0 (0.5) | ||
| UBE3A | −0.9 (1.0) | ||
| Weight for height, mean in SDS (SD) (n = 86)* | 0.35 (1.5) | 1.15 (1.2) | 0.67 (1.39) |
| UPD | 1.5 (0.9) | ||
| IC | 1.2 (0.3) | ||
| UBE3A | 0.8 (1.4) | ||
| Tube feeding,b n (% of genetic subgroup)* | 12 (19.4) | 1 (2.6) | 13 |
| UPD | 0 | ||
| IC | 0 | ||
| UBE3A | 1 | ||
| Hyperphagia, n (% of genetic subgroup) | 16 (26) | 16 (42) | 32 |
| UPD | 7 (44) | ||
| IC | 2 (50) | ||
| UBE3A | 7 (39) | ||
| GERb, n (% of genetic subgroup)** | 39 (63) | 11 (29) | 50 |
| Constipationb, n (% of genetic subgroup) | 28 (45) | 10 (26) | 38 |
| Strabismus, n (% of genetic subgroup) | 27 (44) | 13 (34) | 40 |
| Refractive error, n (% of genetic subgroup) | 24 (39) | 11 (29) | 35 |
| Scoliosis, n (% of genetic subgroup) | 14 (23) | 4 (10) | 18 |
Abbreviation: GER, gastro‐esophageal reflux.
a
At most recent measurement.
b
Defined as now or earlier.
*
Deletion versus nondeletion p < .05.
**
Deletion versus nondeletion p < .01.