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. 2019 Jul 23;30(1):106–119. doi: 10.1111/bpa.12760

Figure 1.

Figure 1

Pathological characterization of MS lesions. HLA‐PLP immunohistochemistry of MS autopsy tissue showing the MS lesion characteristics. A. Reactive site with increased density of HLA+ cells with microscopically intact myelin. B. Active lesion with partial demyelination and HLA+ cells throughout the lesion. C. Mixed active/inactive (chronic active) lesion with inactive demyelinated center and a rim of HLA+ cells. D. Inactive lesion (arrow), demyelinated with sparse HLA+ cells. Remyelinated lesion (arrow head), partial myelination with sparse HLA+ cells. E. Leukocortical lesion. F. Intracortical lesion. G. Subpial cortical lesion. Scale bar represents 500 um.