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. 2019 Feb 12;25(1):e12722. doi: 10.1111/adb.12722

Table 2.

ROI, MD, and FA of 5‐HTT+/+ and 5‐HTT−/− rats that underwent sucrose or cocaine self‐administration

5‐HTT+/+ 5‐HTT−/− Statistics
Sucrose Cocaine Sucrose Cocaine Genotype Treatment Genotype × Treatment
Average SEM Average SEM Average SEM Average SEM F P Effect Size (η p 2) F P Effect Size (η p 2) F P Effect Size (η p 2)
Volume,a μL OFC 27 0.8 27 0.8 27 0.6 27 0.4 0.430 0.517 0.014 0.005 0.945 0.000 0.003 0.954 0.000
mPFC 12 0.4 12 0.6 12 0.6 13 0.3 0.177 0.676 0.006 0.212 0.648 0.007 0.016 0.901 0.001
ACC 21 0.3 20 0.7 19 0.6 20 0.3 1.400 0.246 0.043 0.127 0.724 0.004 2.28 0.141 0.068
CPU 82 1.5 83 2.0 80 2.3 82 1.5 1.164 0.289 0.036 0.659 0.423 0.021 0.075 0.787 0.002
Hip 96 1.5 97 2.0 94 2.6 96 1.6 0.343 0.563 0.011 0.314 0.579 0.010 0.07 0.794 0.002
NAc 16 0.5 17 0.6 17 0.4 16 0.5 0.211 0.649 0.007 0.002 0.963 0.000 0.581 0.452 0.018
AMY 27 0.6 25 0.4 24 0.3 23 0.5 d25.911b d0.000b d0.455b 7.057c c0.012c c0.185c 0.711 0.405 0.022
DRN 1 0.0 0.9 0.0 0.9 0.0 0.9 0.0 2.475 0.126 0.074 3.475 0.072 0.101 11.77b 0.002b 0.275b
Insular 46 1.0 45 1.1 44 1.1 43 1.2 3.713 0.063 0.107 0.415 0.524 0.013 0.036 0.852 0.001
CC 37 0.9 34 0.8 33 0.5 34 0.9 c5.413c c0.027c c0.149c 0.308 0.583 0.010 c4.696c c0.038c c0.132c
MD,d mm2/s OFC 2.79E−04 1.02E−05 2.80E−04 6.37E−06 2.84E−04 7.71E−06 2.84E−04 4.66E−06 0.341 0.564 0.011 0.000 1.000 0.000 0.000 1.000 0.000
mPFC 2.76E−04 1.12E−05 2.78E−04 6.34E−06 2.81E−04 8.83E−06 2.80E−04 5.52E−06 0.194 0.663 0.006 0.000 1.000 0.000 0.047 0.830 0.002
ACC 2.83E−04 9.88E−06 2.88E−04 4.69E−06 2.93E−04 6.88E−06 2.90E−04 3.50E−06 0.688 0.413 0.022 0.000 1.000 0.000 0.268 0.608 0.009
CPU 2.73E−04 9.07E−06 2.73E−04 6.15E−06 2.83E−04 6.30E−06 2.77E−04 5.83E−06 1.036 0.317 0.032 0.165 0.688 0.005 0.183 0.671 0.006
Hip 2.96E−04 7.09E−06 2.99E−04 3.83E−06 3.06E−04 6.30E−06 3.02E−04 2.13E−06 1.366 0.251 0.042 0.000 1.000 0.000 0.466 0.500 0.015
NAc 2.70E−04 1.28E−05 2.68E−04 8.62E−06 2.73E−04 8.72E−06 2.68E−04 7.24E−06 0.000 1.000 0.000 0.117 0.734 0.004 0.000 1.000 0.000
AMY 2.77E−04 1.30E−05 2.76E−04 9.33E−06 2.79E−04 9.17E−06 2.77E−04 6.65E−06 0.024 0.879 0.001 0.000 1.000 0.000 0.000 1.000 0.000
DRN 2.67E−04 1.30E−05 2.72E−04 7.63E−06 2.77E−04 8.13E−06 2.73E−04 3.32E−06 0.376 0.544 0.012 0.000 1.000 0.000 0.194 0.663 0.006
Insular 2.86E−04 1.06E−05 2.88E−04 6.82E−06 2.95E−04 7.26E−06 2.92E−04 5.18E−06 0.653 0.425 0.021 0.000 1.000 0.000 0.077 0.784 0.002
CC 2.15E−04 8.35E−06 2.12E−04 6.10E−06 2.19E−04 7.00E−06 2.10E−04 3.10E−06 0.000 1.000 0.000 0.791 0.381 0.025 0.165 0.687 0.005
FAd OFC 0.218 0.006 0.218 0.004 0.218 0.005 0.221 0.002 0.059 0.81 0.002 0.068 0.796 0.002 0.074 0.788 0.002
mPFC 0.233 0.009 0.233 0.007 0.236 0.005 0.234 0.006 0.112 0.74 0.004 0.022 0.882 0.001 0.026 0.872 0.001
ACC 0.233 0.009 0.236 0.006 0.242 0.005 0.235 0.005 0.326 0.572 0.010 0.068 0.796 0.002 0.475 0.496 0.015
CPU 0.207 0.008 0.203 0.005 0.211 0.005 0.204 0.002 0.108 0.745 0.003 0.840 0.366 0.026 0.059 0.810 0.002
Hip 0.236 0.004 0.235 0.002 0.234 0.002 0.235 0.002 0.228 0.636 0.007 0.000 0.989 0.000 0.162 0.690 0.005
NAc 0.255 0.012 0.249 0.009 0.249 0.008 0.246 0.005 0.224 0.639 0.007 0.18 0.674 0.006 0.033 0.856 0.001
AMY 0.244 0.012 0.240 0.008 0.23 0.008 0.237 0.006 0.863 0.360 0.027 0.031 0.86 0.001 0.359 0.553 0.011
DRN 0.207 0.014 0.191 0.015 0.183 0.010 0.178 0.006 1.925 0.175 0.058 0.653 0.425 0.021 0.182 0.673 0.006
Insular 0.209 0.006 0.209 0.003 0.207 0.005 0.202 0.003 0.984 0.329 0.031 0.343 0.563 0.011 0.242 0.626 0.008
CC 0.587 0.012 0.587 0.009 0.596 0.008 0.584 0.008 0.101 0.753 0.003 0.378 0.543 0.012 0.400 0.531 0.013

Abbreviations: ACC, anterior cingulate cortex; AMY, amygdala; CC, corpus callosum; CPU, caudate putamen; DRN, dorsal raphe nucleus; FA, fractional anisotropy; 5‐HTT, serotonin transporter; Hip, hippocampus; insular, insular cortex; MD, mean diffusivity; mPFC, medial prefrontal cortex; NAc, nucleus accumbens; ROI, region of interest; SEM, standard error of the mean.

a

Data acquired from anatomical data.

b

Effect significant after Benjamini‐Hochberg correction.

c

Effect significant without correction for multiple testing.

d

Data acquired from diffusion tensor imaging (DTI) data.