Figure 6.

Virus‐like particle (VLP)‐based vaccines against breast cancer. (a) A schematic diagram of the structure of the HER‐2 receptor. The extracellular part consists of four domains: Domain I, Domain II (CR1), Domain III and Domain IV (CR2). The other domains are single transmembrane domain, juxtra membrane domain, tyrosine‐kinase domain and finally a C‐terminal tail. (b) SpyTag/SpyCatcher VLP‐based vaccine based on displaying the subdomains I–IV of HER‐2 combined to SyCatcher covalently attached to AP205‐VLP outer surface fused to a SpyTag part