Table 3.

Univariate and Multivariate Analyses of Various Prognostic Parameters in Patients with HCC Cox-regression Analysis for OS

	Univariate Analysis			Multivariate Analysis
	P-value	HR	95% CI	p-value	HR	95% CI
miR-449a	0.008*	0.241	0.085–0.687	0.014*	0.265	0.092–0.762
Notch1	0.943	0.966	0.372–2.504
Age(y)	0.317	0.611	0.232–1.606
Gender	0.339	2.054	0.469–8.987
AFP	0.298	1.697	0.626–4.596
Tumor number	0.082	3.725	0.848–16.371
Tumor size (cm)	0.537	1.389	0.489–3.946
Tumor margin (cm)	0.137	0.452	0.159–1.287
Pathologic differentiation	0.033*	2.833	1.086–7.386
Vascular invasion	0.969	0.976	0.280–3.400
Capsule invasion	0.276	1.712	0.650–4.507
Liver cirrhosis	0.071	0.353	0.114–1.091
HBV infection	0.224	0.498	1.162–1.530

Note: *p < 0.05, statistically significant.