Comparison 5. Augment current antidepressant with cariprazine (antipsychotic).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Depressive symptoms (MADRS)	1		Mean Difference (Fixed, 95% CI)	Subtotals only
1.1 1‐2 mg/d	1	537	Mean Difference (Fixed, 95% CI)	‐0.9 [‐2.29, 0.49]
1.2 2‐4.5mg/d	1	535	Mean Difference (Fixed, 95% CI)	‐2.1 [‐3.63, ‐0.57]
1.3 Any dose	1	808	Mean Difference (Fixed, 95% CI)	‐1.50 [‐2.74, ‐0.25]
2 Dropouts	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.1 1‐2 mg/d	1	545	Risk Ratio (M‐H, Fixed, 95% CI)	1.43 [0.94, 2.17]
2.2 2‐4.5mg/d	1	545	Risk Ratio (M‐H, Fixed, 95% CI)	1.92 [1.30, 2.84]
2.3 Pooled dose	1	821	Risk Ratio (M‐H, Fixed, 95% CI)	1.68 [1.16, 2.41]
3 Response (≥ 50% improvement in MADRS score)	1		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
3.1 1‐2 mg/d	1	537	Risk Ratio (M‐H, Random, 95% CI)	1.25 [1.03, 1.53]
3.2 2‐4.5mg/d	1	535	Risk Ratio (M‐H, Random, 95% CI)	1.29 [1.06, 1.57]
3.3 Pooled dose	1	808	Risk Ratio (M‐H, Random, 95% CI)	1.27 [1.07, 1.52]
4 Remission (MADRS total score ≤ 10)	1		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
4.1 1‐2mg/d	1	537	Risk Ratio (M‐H, Random, 95% CI)	1.06 [0.83, 1.37]
4.2 2‐4.5mg/d	1	535	Risk Ratio (M‐H, Random, 95% CI)	1.07 [0.83, 1.38]
4.3 Pooled data	1	808	Risk Ratio (M‐H, Random, 95% CI)	1.07 [0.86, 1.33]