Table 3. Calculation of combination indices (CI values) of the sequential combination treatments for 1 week.

CI values
	KURAMOCHI	OVSAHO	CAOV3	Patient #1	Patient #2
Carboplatin 5 µM + Olaparib 2.5 µM	0.93	0.80	0.96	1.00	2.85
Carboplatin 5 µM + Olaparib 5 µM	0.84	0.84	1.02	0.90	1.01
Carboplatin 2.5 µM + Olaparib 2.5 µM	0.96	0.94	0.96	0.93	1.50
Carboplatin 2.5 µM + Olaparib 5 µM	0.91	0.90	1.22	1.36	5.48
Carboplatin 5 µM + Niraparib 2.5 µM	1.09	1.01	0.99	N/A	1.10
Carboplatin 5 µM + Niraparib 5 µM	0.88	0.80	0.89	N/A	1.17
Carboplatin 2.5 µM + Niraparib 2.5 µM	2.16	1.32	1.14	N/A	0.47
Carboplatin 2.5 µM + Niraparib 5 µM	1.91	1.12	1.55	N/A	1.23
Olaparib 5 µM + LY 2.5 µM	0.94	0.91	0.88	0.89	2.58
Olaparib 5 µM + LY 5 µM	1.00	0.97	0.95	0.26	1.23
Olaparib 2.5 µM + LY 2.5 µM	1.00	0.98	0.93	1.31	1.35
Olaparib 2.5 µM + LY 5 µM	1.05	1.01	1.13	1.26	1.14
Crizotinib 5 µM + Olaparib 5 µM	0.74	0.75	0.69	0.79	1.06
Crizotinib 5 µM + Olaparib 2.5 µM	0.73	0.69	0.63	0.77	1.04
Crizotinib 2.5 µM + Olaparib 5 µM	0.68	0.70	0.68	0.65	0.93
Crizotinib 2.5 µM + Olaparib 2.5 µM	0.86	0.70	0.62	0.61	1.15
Crizotinib 5 µM + Niraparib 2.5 µM	0.80	0.75	0.74	N/A	1.21
Crizotinib 5 µM + Niraparib 5 µM	0.81	0.81	0.77	N/A	1.07
Crizotinib 2.5 µM + Niraparib 2.5 µM	0.98	0.76	0.71	N/A	0.91
Crizotinib 2.5 µM + Niraparib 5 µM	0.80	0.74	0.71	N/A	0.91

CI values in bold indicate the drug concentrations selected for further experiments, sd < 3%.

N/A, not available.