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. 2019 Dec 10;10(65):6997–7009. doi: 10.18632/oncotarget.27367

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Copyright: Ding et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) Western blot analysis of lung lysates from control, Sesn2^-/-, Sesn1^-/-, and Sesn1^F/F animals. (B–D) Sesn1^-/-; Sesn2^-/-;Kras^LSL-G12D and Sesn2^-/-;Kras^LSL-G12D animals produce tumors of similar morphology (B), number (C), and size (D). 4 mice were analyzed per group. The data in (C) and (D) are presented as mean ± S.D. P values were calculated using a two-tailed student’s t-test; n.s. – not significant. (E) Sesn2^-/-;Kras^LSL-G12D and Sesn1^-/-;Sesn2^-/-;Kras^LSL-G12D animals have a similar lifespan. 12 mice were analyzed per group.