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. 2019 Jul 24;104(12):5737–5750. doi: 10.1210/jc.2019-00631

Figure 4.

Figure 4.

Human L1CAM expression during embryonic development. (A and B) A human embryonic section from CS19 showing L1CAM mRNA transcripts in the developing hypothalamus (Hyp), ventral diencephalon (VD), and trigeminal ganglia (TG). (B) mRNA transcripts can be seen in the spinal cord (S). In a different embryo section at (C) CS19 and at (D) CS20, L1CAM expression is noted throughout the metencephalon (M) and again in the TG. There is no mRNA transcript staining in the RP at either stage. (E) In a different embryo section at CS20, specific expression is seen throughout the hypothalamus and in the TG. (F) At CS23, L1CAM expression is observed ubiquitously throughout the brain, particularly in the M; (G) it is also present in the retina (R) of the eye. (H) A different embryo section at CS23 shows that L1CAM expression is partially maintained in the Hyp and TG. (I) At CS23, there is strong expression in the telencephalon (T) (forebrain).