CypD-binding drugs repress UVA-induced cell death. HaCaT cells were subjected to repetitive UVA irradiation in the presence of vehicle, CsA, tacrolimus (Tac), or NIM811 (NIM) at 125nM and 250nM and analyzed by flow cytometry. The data are expressed as values relative to vehicle, which is set at 0. (a) Viable cells excluded Ann V-PE and 7-AAD. (b) Apoptotic cells stained with Ann V-PE and, (c), necrotic cells stained with Ann V-PE and 7-AAD or 7-AAD. Data represent means ± s.e.m. n=3. Asterisks indicate significant differences compared to vehicle treated cells, *P < 0.05.