Table 3.
Partial correlations of cognitive composites with APP‐derived CSF biomarkers after adjusting by age, sex, and education in the FTLD‐related syndromes group.
| Aβ1‐42 | Aβ1‐40 | Aβ1‐38 | sAPPβ | |
|---|---|---|---|---|
| Memory | n.s | n.s | n.s | n.s |
| Executive function |
0.41 (0.19–0.61) P = 0.001 * |
0.31 (0.05–0.56) P = 0.017 | 0.35 (0.12–0.57) P = 0.006 | 0.34 (0.13–0.53) P = 0.007 |
| Language | n.s | n.s | n.s | n.s |
| Visuospatial |
0.34 (0.09–0.56) P = 0.009 |
n.s | 0.37 (0.13–0.58) P = 0.004 | n.s |
Correlation between Aβ(1‐42), Aβ(1‐40), and Aβ(1‐38) and sAPPβ in (A) AD group, (B) FTLD‐related syndromes group, and (C) healthy control group. Results are shown as Pearson correlation coefficient (95% confidence interval). 95% confidence intervals were calculated by means of bias‐corrected accelerated bootstrapping (1000 samples). Significant correlations (P < 0.05) are marked in bold. APP, amyloid precursor protein; Aβ, amyloid β; CSF, cerebrospinal fluid; FTLD, frontotemporal lobar degeneration; n.s, non‐significant correlation.
Remained significant after adjusting for multiple comparisons (Bonferroni).