Table 2.

Generalized estimate equations multivariate models of demographic and clinical factors associated with worsened cognitive function (N = 1092)^a

Variable	Poor Memory				Word‐Finding Difficulty				Poor Concentration
	95% CI				95% CI				95% CI
	OR	lower	upper	P value	OR	lower	upper	P value	OR	lower	upper	P value
Physically activeb	0.83	0.72	0.96	0.01*	0.45	0.30	0.67	0.0001*	0.82	0.77	0.87	<0.0001*
Anti‐TNF use	0.69	0.53	0.90	0.01*	1.14	0.71	1.83	0.58	0.75	0.54	1.06	0.10
DAS28‐CRP3	1.07	0.98	1.17	0.14	1.02	0.91	1.13	0.78	1.07	0.99	1.17	0.09
Gender (female)	2.67	0.80	8.90	0.11	1.21	0.46	3.22	0.70	4.88	1.13	21.12	0.03*
Depression score (MHI‐D)	0.99	0.90	1.09	0.82	1.05	0.97	1.14	0.22	0.97	0.92	1.02	0.24
Methotrexate use	0.83	0.60	1.16	0.28	0.78	0.51	1.19	0.25	1.06	0.77	1.45	0.72
Corticosteroid use	0.92	0.62	1.37	0.69	0.99	0.62	1.56	0.95	1.22	0.96	1.54	0.11
BMI	1.00	0.96	1.04	0.82	1.00	0.96	1.03	0.92	0.98	0.93	1.03	0.46
Education (college degree or more)	0.83	0.44	1.55	0.55	0.83	0.42	1.66	0.60	0.84	0.41	1.72	0.63
Sleep difficulties (MDHAQ)	1.09	0.82	1.45	0.54	0.99	0.77	1.26	0.92	1.09	0.92	1.28	0.31
Fatigue (VAS)	1.00	0.99	1.01	0.70	1.00	1.00	1.01	0.70	1.00	0.99	1.00	0.36
Age, y	1.00	0.98	1.02	1.00	1.00	0.97	1.02	0.78	0.99	0.97	1.01	0.48

Abbreviation: CI, confidence interval; DAS28‐CRP, Disease Activity Score 28 joints–c‐reactive protein; MDHAQ, Multidimensional Health Assessment Questionnaire; MHI‐D, Mental Health Index‐Depression; OR, odds ratio; TNF, tumor necrosis factor; VAS, visual analog scale.

^aAdjusted for time (days) between questionnaires. ^bMeeting the US Department of Health and Human Services recommendation for physical activity.

^* P < 0.05.