Table 3.

Associations of vascular risk burden and neuropathology outcomes.

Outcome	Mid‐life vascular risk Model 1		Mid‐life vascular risk Model 2		Late‐life vascular risk Model 3
	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P
Cerebrovascular pathology
Cortical infarcts	3.99 (1.65, 9.65)	0.002*	3.83 (1.55, 9.45)	0.004*	1.04 (1.00, 1.08)	0.049*
Subcortical infarcts	1.95 (1.07, 3.54)	0.029*	1.85 (1.01, 3.40)	0.047*	1.02 (0.99, 1.06)	0.129
Atherosclerosis	1.89 (1.17, 3.06)	0.009*	1.90 (1.16, 3.10)	0.011*	1.02 (1.00, 1.05)	0.070
Arteriosclerosis	1.86 (1.15, 3.02)	0.012*	1.78 (1.09, 2.90)	0.022*	1.03 (1.00, 1.05)	0.024*
Proteinopathy
Braak NFT stage	1.15 (0.73, 1.82)	0.554	1.18 (0.74, 1.89)	0.484	1.03 (1.01, 1.05)	0.012*
Cerebral amyloid angiopathy	1.15 (0.71, 1.86)	0.575	1.19 (0.72, 1.95)	0.494	1.02 (1.00, 1.05)	0.061
CERAD neuritic plaque score	0.86 (0.54, 1.37)	0.525	0.86 (0.54, 1.39)	0.547	1.02 (1.00, 1.05)	0.052

OR, Odds ratio; CI, confidence interval; P, P‐value; CERAD, Consortium to Establish a Registry for Alzheimer's Disease.

Model 1: Adjusted for gender, presence of ApoE ɛ4, and elapsed time between mid‐life vascular risk and death (with quadratic term for atherosclerosis and arteriosclerosis).

Model 2: Model 1 additionally adjusted for late‐life vascular risk.

Model 3: Adjusted for gender, presence of ApoE ɛ4, and elapsed time between late‐life vascular risk and death.

^* P < 0.05.