Table 1.
Participants included in this study
| CU | MCI | Dementia | Total | P‐value | |
|---|---|---|---|---|---|
| Total N | 420 | 482 | 146 | 1048 | |
| Age, mean ± SD (range) | 73.8 ± 5.79 (56.2–90.0) | 72.4 ± 7.35 (55–91.4) | 74.6 ± 8.21 (55.7–90.3) | 73.3 ± 6.95 (55–91.4) | CU> MCI: 0.016 |
| MCI < DEM: 0.002 | |||||
| Female, n (%) | 220 (52.4%) | 197 (40.9%) | 60 (41.1%) | 477 (45.5%) | CU> MCI: <0.001 |
| MCI‐DEM: 0.96 | |||||
| Education, mean ± SD (range) | 16.5 ± 2.61 (6–20) | 16.1 ± 2.83 (6–20) | 15.7 ± 2.68 (9–20) | 16.2 ± 2.74 (6–20) | CU> MCI: 0.04 |
| MCI‐DEM: 0.12 | |||||
| MMSE | 29 ± 1.18 (24–30) | 27.8 ± 1.76 (24–30) | 23.1 ± 2.13 (19–28) | 27.6 ± 2.5 (19–30) | CU> MCI: <0.001 |
| MCI> DEM: <0.001 | |||||
| ApoE ε4+ | 117 (27.9%) | 238 (49.4%) | 97 (66.4%) | 452 (43.1%) | CU < MCI: <0.001 |
| MCI < DEM: <0.001 | |||||
| Aβ+, N (%) | 135 (36.1%) | 264 (61.7%) | 125 (85.6%) | 524 (50.0%) | CU < MCI: <0.001 |
| MCI < DEM: <0.001 | |||||
| SP‐ECog, mean ± SD (range) | 1.23 ± 0.335 (1–3.35) | 1.95 ± 0.759 (1–3.97) | 2.73 ± 0.662 (1.13–3.95) | 1.77 ± 0.794 (1–3.97) | CU < MCI: <0.001 |
| MCI < DEM: <0.001 | |||||
| Self‐ECog, mean ± SD (range) | 1.41 ± 0.336 (1–2.74) | 1.81 ± 0.56 (1–3.82) | 1.89 ± 0.6 (1–3.66) | 1.66 ± 0.531 (1–3.82) | CU < MCI: <0.001 |
| MCI‐DEM: 0.14 |
CU, Cognitively Unimpaired; MCI, Mild Cognitive Impairment; DEM, Dementia; MMSE, Mini Mental Status Exam. P‐values represent differences between indicated diagnostic groups, based on Mann–Whitney text for continuous variables or Chi‐square test for categorical variables. P values less than 0.05 are indicated by bold italics.